From: Genome-wide characterisation of the binding repertoire of small molecule drugs
Drug | Target | Physiological effect | Experimentally confirmed? |
---|---|---|---|
Taxol™ | β-Tubulin | Mitotic block | Yes[2] |
 | Bcl-2 | Apoptosis | Yes[3] |
 | P-glycoprotein | Drug resistance | |
 | CD18 | LPS-like activity | Yes[6] |
 | Topoisomerase II | Mitotic block? | Yes[7] |
 | Hsp90 | ? | Yes[8] |
Aspirin | COX | Anti-inflammatory activity | Yes[9] |
 | IKKKβ | Anti-inflammatory activity | Yes[10] |
 | Carbonic anhydrase | Anti-inflammatory activity | Yes[11] |
 | Antithrombin III | Anticoagulant activity | Yes[12] |
 | LCHAD | Beta-oxidation inhibition | Yes[13] |
 | Fatty acid-binding protein | Peroxisome proliferator activity | Implied[14] |
Gentamicin | 16S ribosomal RNA | Antibiotic activity | Yes[15] |
 | α9 nAChR | Side effects on organ of Corti | |
 | Glutamate dehydrogenase | Nephrotoxicity | Yes[18] |
 | Steroidogenic enzymes? | Sperm count decline | Implied[19] |
Ibuprofen | Prostaglandin H(2) synthase-I | Anti-inflammatory activity | Yes[20] |
 | Steroid sulfotransferase | Toxicity | Yes[21] |
 | ? | PMN migration inhibition | Implied[22] |
Saquinavir | HIV protease | Anti-HIV activity | Yes[23] |
 | PPARγ | Fat metabolism effects | Yes[24] |
Neomycin B | 16S ribosomal RNA | Antibiotic activity | Yes[25] |
 | Multiple ribozymes | ? | |
 | α9 nAChR | Side effects on organ of Corti | Yes[16] |
 | Inositol phospholipids | Inhibition of phospholipase C | Yes[28] |
 | RRE RNA from HIV | Anti-HIV activity | Yes[29] |
 | Glutamate dehydrogenase | Nephrotoxicity | Yes[18] |
Penicillin | β-Lactamase | Antibiotic activity | Yes[30] |
 | GSH S-transferase | ? | Yes[31] |
 | ? | IFN-γ modulation | Implied[32] |
Genistein | Tyrosine protein kinase | Multiple cellular effects | |
 | Topoisomerase I and II | Multiple cellular effects | |
 | Oestrogen receptor β | Partial agonist activity | |
Fluoroquinolones | GyrA gene product | Antibiotic activity | Yes[40] |
 | ParC (topoisomerase IV) gene product | Antibiotic activity | |
CGP64222 | HIV TAR RNA | Anti-HIV activity | Yes[43] |
 | CXCR4 coreceptor | Anti-HIV activity | Yes[44] |
Flavopiridol | Cyclin-dependent kinase | Anti-cancer activity | Yes[45] |
 | Duplex DNA | Anti-cancer activity | Yes[46] |
Coumarins | DNA gyrase | Antibiotic activity | Yes[47] |
 | hel gene product(s) | Antibiotic activity | Possible[48] |